Journal article
Exposure to adversity and inflammatory outcomes in mid and late childhood
Meredith O'Connor, Anne-Louise Ponsonby, Fiona Collier, Richard Liu, Peter D Sly, Peter Azzopardi, Kate Lycett, Sharon Goldfeld, Sarah J Arnup, David Burgner, Naomi Priest, Peter Vuillermin, Mimi LK Tang, Richard Saffery, John Carlin, Len Harrison
Brain, Behavior, & Immunity - Health | Elsevier BV | Published : 2020
Abstract
Background: We aimed to estimate the association between exposure to adversity and inflammatory markers in mid (4 years) and late (11–12 years) childhood, and whether effects differ by type and timing of exposure. Methods: Data sources: Barwon Infant Study (BIS; N = 510 analyzed) and Longitudinal Study of Australian Children (LSAC; N = 1156 analyzed). Exposures: Adversity indicators assessed from 0 to 4 (BIS) and 0–11 years (LSAC): parent legal problems, mental illness and substance abuse, anger in parenting responses, separation/divorce, unsafe neighborhood, and family member death; a count of adversities; and, in LSAC only, early (0–3), middle (4–7), or later (10–11) initial exposure. Ou..
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Awarded by National Health and Medical Research Council
Funding Acknowledgements
This study was supported by the Victorian Government's Operational Infrastructure Support Program. This paper uses unit record data from Growing Up in Australia, the Longitudinal Study of Australian Children. The study is conducted in partnership between the Department of Social Services (DSS) , the Australian Institute of Family Studies (AIFS) and the Australian Bureau of Statistics (ABS) . We also draw on data from the Barwon Infant Study, and would like to thank the study participants, as well as the entire BIS team which includes interviewers, nurses, computer technicians, clerical workers, research scientists, volunteers, managers and receptionists. We also thank the obstetric and midwifery teams at Barwon Health and Saint John of God Hospital Geelong for their assistance in recruitment and collection of biological specimens. The establishment work and infrastructure for the BIS was provided by the Murdoch Children's Research Institute, Deakin University and Barwon Health. Subsequent funding was secured from the National Health and Medical Research Council of Australia, The Jack Brockhoff Foundation, the Scobie Trust, the Shane O'Brien Memorial Asthma Foundation, the Our Women's Our Children's Fund Raising Committee Barwon Health, The Shepherd Foundation, the Rotary Club of Geelong, the Ilhan Food Allergy Foundation, GMHBA Ltd, The Gandel Foundation, The Percy Baxter Charitable Trust, Perpetual Trustees and the Gwenyth Raymond Trust. Vanguard Investments Australia Ltd provided funding for analysis of plasticizers in biospecimens. In-kind support was provided by the Cotton On Foundation and CreativeForce. Meredith O'Connor and Sarah Arnup were supported by the Melbourne Children's LifeCourse initiative, funded by a Royal Children's Hospital Foundation Grant (2018-984) . Anne-Louise Ponsonby is supported by a National Health and Medical Research Council (NHMRC) Fellowship (1110200) . Peter Sly is supported by an NHMRC Fellowship (APP1102590) . Naomi Priest is supported by an NHMRC Career Development Fellowship (APP1123677) . Kate Lycett is supported by an NHMRC Early Career Fellowship (APP1091124) and Honorary National Heart Foundation Postdoctoral Fellowship (101239) . Sharon Goldfeld is supported by an NHMRC Career Development Fellowship (1082922) . David Burgner is supported by an NHMRC Investigator Grant (1175744) . The findings and views reported in this paper are those of the authors only.